Hormones work together like a beautifully choreographed dance.
The thyroid hormones, the adrenal hormones and the sex hormones (estrogen, progesterone, and testosterone) need to be in balance with each other for optimal functioning. Treating a sluggish thyroid is going to be more difficult if you have adrenal fatigue. If you think your moodiness is from your estrogen being out of balance you may be right but there is likely more to it.
For effective treatment and thyroid, adrenal and hormone correction, think of the hormones as the points on an equilateral triangle. If you shift one, they all shift. That is why it is essential to monitor all the hormones, not just some of them. There are differing opinions on what is the most effective way to measure hormones- is it with blood, saliva, or urine? There is something to be said for consistency, and I like to use the same testing method each time to watch the change and fine-tune the treatment.